Welcome to the MANTIS trial website...
The MANTIS trial has now come to a close. Thank you to all of those who were involved or took part in the trial.
The MANTIS trial was led by Professor Siôn Glyn-Jones, a Consultant Orthopaedic Surgeon, based in Oxford. Professor Glyn-Jones has a specialist interest in the treatment of hip arthritis in the young adult patient population and revision hip arthoplasty.
Why do we need the MANTIS trial?
AVN is a condition caused by a lack of blood supply to the bone and in the early stages, symptoms may be minimal. As the condition progresses, people may begin to experience pain and difficulty moving around. Current early phase treatment includes non-weight bearing exercise, the use of walking aids, physiotherapy or pain relief. As the condition progresses, patients may require a hip replacement.
Currently there is very little evidence available regarding the use of medication to help in the treatment of AVN. Some evidence exists to show that oral bisphosphonates may slow down or halt the progression of AVN however this is in small patient populations.
The MANTIS trial therefore wants to invesitgate the effectiveness of bisphosphonates.
The MANTIS Trial is now closed to recruitment.
Our thanks to those who were involved and took part in the trial.
Newsletters and leaflets
Information for Trainees
MANTIS Publication Points
Funding
The MANTIS trial is funded by the National Institute for Health Reasearch (NIHR) Health Technology Assessment (HTA) Programme (15/39/06)
To find out more information about the NIHR and their research, click here
Operational Support
Trial management is supported by the Surgical Intervention Trials Unit (SITU), which is one of seven Royal College of Surgeons of England specialist trials centres.
SITU is part of the registered Oxford Clinical Trials Unit (OCTRU), directed by Professor Sallie Lamb. For more information about the trials unit, click here
