• Managing Avascular Necrosis Treatments: an Investigational Study
  • Managing Avascular Necrosis Treatments: an Investigational Study

Welcome to the MANTIS trial website...

This site is for clinicians and researchers who are interested in getting involved in the MANTIS trial or for those already involved and wanting to find out the latest information.

The MANTIS trial is led by Professor Siôn Glyn-Jones, a Consultant Orthopaedic Surgeon, based in Oxford. Professor Glyn-Jones has a specialist interest in the treatment of hip arthritis in the young adult patient population and revision hip arthoplasty.

Why do we need the MANTIS trial?

AVN is a condition caused by a lack of blood supply to the bone and in the early stages, symptoms may be minimal. As the condition progresses, people may begin to experience pain and difficulty moving around. Current early phase treatment includes non-weight bearing exercise, the use of walking aids, physiotherapy or pain relief. As the condition progresses, patients may require a hip replacement.

Currently there is very little evidence available regarding the use of medication to help in the treatment of AVN. Some evidence exists to show that oral bisphosphonates may slow down or halt the progression of AVN however this is in small patient populations.

The MANTIS trial therefore wants to invesitgate the effectiveness of bisphosphonates and we aim to recruit 280 participants with early, symptomatic, atraumatic AVN of the hip, aged 18 and over, from across the UK.

If you would like to get involved or have any questions, please get in touch with the MANTIS team using the details below or visit the 'Contact Us' page.

Latest News

The MANTIS Trial is now open to recruitment!

Our thanks so far to those who are involved and working hard to reach our milestones.

Contact us today to become a recruiting site or follow us on Twitter 

Related image @mantis_trial

Please note!

This trial is running a publication points scheme for clinicians, trainees and members of the research team.


Recruitment Progress:
Latest participant recruited from: Milton Keynes University Hospitals NHS Foundation Trust
Date of most recent recruitment: Monday, 18th November 2019